Anesthesiology
Alireza Talai; Alireza Moslem; Arash Hamzahee; Mojtaba Kianmehr; Abbasali Abbasnezhad
Volume 27, Issue 1 , May and June 2020, , Pages 1-8
Abstract
Background: Intravenous regional anesthesia is a technique developed by the use of tourniquet and intravenous injection of anesthetic drug in the distal areas of the surgical region of the limbs. The aim of this study was to compare the onset of anesthesia induced by two methods of lidocaine use in regional ...
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Background: Intravenous regional anesthesia is a technique developed by the use of tourniquet and intravenous injection of anesthetic drug in the distal areas of the surgical region of the limbs. The aim of this study was to compare the onset of anesthesia induced by two methods of lidocaine use in regional intravenous anesthesia of the upper extremity.Materials and Methods: This single-blind clinical trial study was performed on 40 patients who referred to Bohlool hospital in Gonabad for forearm surgery. Samples were randomly divided into two receiving 40 ml lidocaine 0.5% and 20 ml lidocaine 1%. The research tool was a Researcher-made checklist and a Visual Analoge Scale (VAS). Fisher's exact test, independent and pair t-test were used for data analysis at a significance level of less than 0.05.Results: The results showed that the interval between the injection of anesthesia until the start of complete anesthesia was significantly shorter in the 20 ml lidocaine 1% recipient group compared to the 40 ml lidocaine 0.5% recipient group (p0.05).Conclusion: Regional intravenous anesthesia is induced by 20 ml lidocaine 1% faster than 40 ml lidocaine 0.5%.Keywords: Lidocaine, Intravenous, Regional anesthesia, Upper extremity
Hasan Ramshini; Abdollah Mehrabadi; Alireza Moslem
Volume 23, Issue 1 , May and June 2016, , Pages 183-195
Abstract
Backgrounds & Objectives: Aggregates of β-amyloid protein are the main constituent of senile plaques and considered to be one of the causative events in the pathogenesis of Alzheimer's disease (AD). Compounds that could inhibit Aβ fibrils formation and or reduce their associated neurotoxicity ...
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Backgrounds & Objectives: Aggregates of β-amyloid protein are the main constituent of senile plaques and considered to be one of the causative events in the pathogenesis of Alzheimer's disease (AD). Compounds that could inhibit Aβ fibrils formation and or reduce their associated neurotoxicity might have therapeutic values for treating AD. Although curcumin has shown promising therapeutic utilities for many diseases, including Alzheimer, its clinical application is severely limited because of its poor stability under physiological conditions. In this study, the inhibitory effects of 2,6-bis(3,4-dimethoxybenzylidene)-1-cyclohexanone on aggregation and neurotoxicity of hen egg white lysozyme (HEWL) and, also, on spatial learning and memory of rats were evaluated. Methods: 30 male wistar rates (250-280 g) were divided into 5 groups: control, received scopolamine, received lysozyme amyloid aggregates, received lysozyme aggregates formed in presence of Curcumin and/or Curcumin derivative. The Morris Water maze was used for studying the spatial learning memory. Results: The results showed that, in comparison with receiver groups of lysozyme aggregates alone, the receiver rats of the aggregates formed in the presence curcumin and its derivative found platform in less time and with less distance traveled. The hippocampal injection of HEWL aggregates damaged the spatial memory of rates. Meanwhile amyloid aggregates formed in presence of curcumin or curcumin derivative were nontoxic and had no significant effect on spatial memory in rats. Conclusions: These observations suggest that Curcumin and its derivativeare are capable to insert directly into amyloidogenic core of early aggregates and inhibiting amyloid fibril formation. Also, this study showed the importance of using model proteins as a valid tool to investigate the pathogenesis of Alzheimer’s disease.
Somayyeh Zamiri; Sakineh Azizi; Aghdas Shakeri; Zahra HasanDoost; Mozhdeh Mohammaddost; Hamideh Yosefi; Alireza Moslem; Arash Akaberi
Volume 23, Issue 2 , March and April 2016, , Pages 196-203
Abstract
Background & Objectives: Spiritual intelligence represents a different set of skills and abilities that each of them is displayed in different forms in social and historical contexts; and self-efficacy is one's belief in own abilities to solve problems and deal with problems. The purpose of this ...
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Background & Objectives: Spiritual intelligence represents a different set of skills and abilities that each of them is displayed in different forms in social and historical contexts; and self-efficacy is one's belief in own abilities to solve problems and deal with problems. The purpose of this study was to determine if spiritual intelligence can predict self-efficacy. Methods: This cross-sectional analytical study was carried out among students of North Khorasan University of Medical Sciences in the year 2012. 129 individuals were selected via Stratified sampling method. Individuals were assessed by spiritual intelligence questionnaire and Self Efficacy Scale (SES). Data was analyzed by Pearson correlation coefficient, t-student test and linear multiple regression (stepwise), by SPSS 20 software. The p-value was considered 0.05. Results: Results show that the correlation between spiritual intelligence and self-efficacy was statistically significant (r=0.612, p-value<0.001). In predicting self-efficacy by spiritual intelligence and adjusting other variables effect such as gender, age, habitat, university grade point average by multiple regression tests (stepwise), the results determine that spiritual intelligence can significantly predict self-efficacy score. Conclusion: The conclusion of the study is that spiritual intelligence is prolific in predicting self-efficacy. So, you can promote students' spiritual intelligence skills, to increase their self-efficacy in academic, social and family affairs.
Benyamin Alimohammadi; Alireza Moslem; Hassan Azhdari Zarmehri; Homan Kamranian
Volume 23, Issue 2 , March and April 2016, , Pages 204-213
Abstract
Background and Objectives: Nowadays the use of herbal plants due to their low complications attracts the mind of many scientists. The aim of this study is the assessment of the Naloxone as an antagonist of opioids on seizure duration time induced by PTZ and determine the anticonvulsant mechanism of hydro ...
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Background and Objectives: Nowadays the use of herbal plants due to their low complications attracts the mind of many scientists. The aim of this study is the assessment of the Naloxone as an antagonist of opioids on seizure duration time induced by PTZ and determine the anticonvulsant mechanism of hydro alcoholic extract of Scrophularia striata Boiss. Materials & Methods: In the present study, 40 male mice were randomly divided into five groups of eight; The control group (receiving PTZ 80 mg/kg, i.p.), Two treatment groups (Scrophularia striata 600 and 900 mg/kg, i.p.) and two experimental groups (Scrophularia striata 600 and 900 mg/kg i.p plus Naloxone 5 mg/kg, i.p., 5 minutes before extract injection). With injection of PTZ, convulsive behaviors in mice during 20 minutes were recorded by camera and the various stages of seizures were evaluated. Statistical data were analyzed using with the tests of one way Variance and Tukey in SPSS 16. PResults: Statistical analysis showed that Naloxone injection with extract administration have slightly and not significantly decreased the latency time to tonic and clonic seizure in comparison with the control group. Latency time to tonic-colonic has been increased in extract only group and extract associated Naloxone group. With injection of the extract alone total seizure time has decreased but in extract associated Naloxone group this time has increased that this increasing in dose of 600 mg/kg is significant in comparison with control group (P<0.01). Data showed that extract injection lonely and associated with Naloxone have increased the duration time of tonic seizure, duration time of tonic-colonic with extract injection was increased but this time in Naloxone group has been slightly decreased. Conclusion: Our study indicated that Naloxone as an antagonist can inhibit the anticonvulsant activity of hydro alcoholic extract of Scrophularia striata Boiss.
Siavoosh Dodangeh; Alireza Moslem; Marjan Vojdani; Mahnaz Narimani Zamanabadi; Mohammad Mansouri nasab; Hesam Abdolhosseinpour
Volume 23, Issue 2 , March and April 2016, , Pages 370-376
Abstract
Background & Objectives: Vertebroplasty is a new and effective treatment for strengthening broken vertebra and reducing the pain arisen from osteoporotic fractures. This study was performed to determine the pain reduction effect of percutaneous vertebroplasty with calcium phosphate in traumatic vertebral ...
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Background & Objectives: Vertebroplasty is a new and effective treatment for strengthening broken vertebra and reducing the pain arisen from osteoporotic fractures. This study was performed to determine the pain reduction effect of percutaneous vertebroplasty with calcium phosphate in traumatic vertebral fractures in patients attending to Laleh, Mehrad and Booali Hospitals in 2012. Materials & Methods: In this quasi-experimental study, 18 patients with traumatic fractures in Laleh, Mehrdad and Bu Ali hospitals were studied during the year 2012. The method of purposeful non-probability sampling was used and ethical issues were carefully considered. Pain intensity were determined and compared based on Visual Analog Scale in 3 phases; before and immediately after percutaneous surgery and vertebroplasty with calcium carbonate, and 6 months later. The data were analyzed using SPSS software and descriptive statistic method. Results: In this study, at first, the mean preoperative VAS was 8.2 that, subsequently, decreased to 1.68 and zero. Comparison of preoperative and postoperative pain severities demonstrated that 79.6% reduction was observed in the pain and later this amount was increased to 100%. Overly, there was not a relationship between changes in VAS and variables such as leakage in patients, age, calcium carbonate amount, gender and level of involvement. Conclusions: It may be concluded that percutaneous vertebroplasty with calcium phosphate is effective in patients with traumatic vertebral fractures. Choosing the right patient, precise needle placement with fluoroscopic guide, timely injection of cement and experience play key roles in the success of this method.